We evaluated the potential utility of imaging parameters derived by normalizing muscle signal intensity on T1-weighted lower leg MRIs in Charcot-Marie-Tooth disease type 1 A (CMT1A) patients, using a deep learning-based automated muscle segmentation ...
BACKGROUND AND OBJECTIVES: Intramuscular fat fraction (FF), assessed with quantitative MRI (qMRI), has emerged as one of the few responsive outcome measures in CMT1A patients. The main limitation for its use in future therapeutic trials is the time r...
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