Automated segmentation of brain metastases with deep learning: A multi-center, randomized crossover, multi-reader evaluation study.

Journal: Neuro-oncology
PMID:

Abstract

BACKGROUND: Artificial intelligence has been proposed for brain metastasis (BM) segmentation but it has not been fully clinically validated. The aim of this study was to develop and evaluate a system for BM segmentation.

Authors

  • Xiao Luo
    Department of Spine Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.
  • Yadi Yang
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Shaohan Yin
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Hui Li
    Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Ying Shao
  • Dechun Zheng
    Department of Radiology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
  • Xinchun Li
    Guangxi Key Laboratory of Pharmaceutical Precision Detection and Screening, Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening of Guangxi Education Department, Pharmaceutical College, State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China.
  • Jianpeng Li
    Department of Cardiology, Taizhou Second People's Hospital, The Affiliated Taizhou Second People's Hospital of Yangzhou University, Taizhou, China.
  • Weixiong Fan
    Department of Magnetic Resonance, Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital, Meizhou, China.
  • Jing Li
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
  • Xiaohua Ban
    Imaging Diagnostic and Interventional Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
  • Shanshan Lian
    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guang zhou, Guangdong Province, China.
  • Yun Zhang
    Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
  • Qiuxia Yang
    Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
  • Weijing Zhang
    Imaging Department, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
  • Cheng Zhang
    College of Forestry, Jiangxi Agricultural University, Nanchang, Jiangxi Province, China.
  • Lidi Ma
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Yingwei Luo
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Fan Zhou
  • Shiyuan Wang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
  • Cuiping Lin
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Jiao Li
    CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences Guangzhou 510301 China yinhao@scsio.ac.cn.
  • Ma Luo
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Jianxun He
    Department of Civil Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
  • Guixiao Xu
    Department of Radiology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China. xugx@sysucc.org.cn.
  • Yaozong Gao
  • Dinggang Shen
    School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
  • Ying Sun
    CFAR and I2R, Agency for Science, Technology and Research, Singapore.
  • Yonggao Mou
    Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guang zhou, Guangdong Province, China.
  • Rong Zhang
    Internal Medicine - Cardiology Division, UT Southwestern, Dallas, TX, USA.
  • Chuanmiao Xie
    Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.