Improving the prediction of chemotherapy dose-limiting toxicity in colon cancer patients using an AI-CT-based 3D body composition of the entire L1-L5 lumbar spine.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
PMID: 39707027

Abstract

PURPOSE: Chemotherapy dose-limiting toxicities (DLT) pose a significant challenge in successful colon cancer treatment. Body composition analysis may enable tailored interventions thereby supporting the mitigation of chemotherapy toxic effects. This study aimed to evaluate and compare the effectiveness of using three-dimensional (3D) CT body composition measures from the entire lumbar spine levels (L1-L5) versus a single vertebral level (L3), the current gold standard, in predicting chemotherapy DLT in colon cancer patients.

Authors

  • Ke Cao
    The Third Xiangya Hospital, Central South University, Changsha, China.
  • Josephine Yeung
    Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Victoria, Australia.
  • Matthew Y K Wei
    Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Victoria, Australia.
  • Cheuk Shan Choi
    Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Australia.
  • Margaret Lee
    Department of Medical Oncology, Western Health, Melbourne, Victoria, Australia.
  • Lincoln J Lim
    Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Australia.
  • Yasser Arafat
    Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Victoria, Australia.
  • Paul N Baird
    Department of Surgery, Ophthalmology, University of Melbourne, Parkville, Victoria, Australia.
  • Justin M C Yeung
    Department of Colorectal Surgery, Western Health, Melbourne, Australia.

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