Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.

Journal: BioMed research international
PMID: 26798640

Abstract

INTRODUCTION: Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant impact on the differentiation behaviour of hMSCs. Here, we investigate the effect of 2-hour IL-1β stimulation on the differentiation and paracrine activity of hMSCs in coculture with osteosarcoma cells in vitro.

Authors

  • Jan O Voss
    AO Research Institute Davos, 7270 Davos Platz, Switzerland; Department of Oral and Maxillofacial Surgery/Clinical Navigation, Charité-Universitätsmedizin Berlin, Campus Virchow-Clinic, 13353 Berlin, Germany.
  • Claudia Loebel
    AO Research Institute Davos, 7270 Davos Platz, Switzerland.
  • Jennifer J Bara
    AO Research Institute Davos, 7270 Davos Platz, Switzerland.
  • Marc Anton Fussinger
    AO Research Institute Davos, 7270 Davos Platz, Switzerland; Department of Oral and Maxillofacial Surgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
  • Fabian Duttenhoefer
    Department of Oral and Maxillofacial Surgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
  • Mauro Alini
    AO Research Institute Davos, 7270 Davos Platz, Switzerland.
  • Martin J Stoddart
    AO Research Institute Davos, 7270 Davos Platz, Switzerland.

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