AIMC Topic: Osteosarcoma
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Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier.
Journal of translational medicine
Jul 7, 2025
BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provide...
LncRNAs regulates cell death in osteosarcoma.
Scientific reports
Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
PET image nonuniformity texture features for metastasis risk prediction in osteosarcoma.
Nuclear medicine communications
May 6, 2025
OBJECTIVE: PET image analysis provides tumor heterogeneity data related to neoadjuvant chemotherapy response (NACR) and metastatic risk in osteosarcoma. Ki-67 expression is used to predict metastasis. The accuracy of prediction models with image quan...
Prediction of High-Dose Methotrexate Blood Concentration in Osteosarcoma Patients Using Machine Learning.
Drug design, development and therapy
May 3, 2025
INTRODUCTION: High-dose methotrexate is a typical chemotherapy that is widely used in the treatment of osteosarcoma. However, the unique dose-response relationship of methotrexate makes its treatment window relatively narrow, and its clinical use is ...
Improved gated recurrent unit-based osteosarcoma prediction on histology images: a meta-heuristic-oriented optimization concept.
Scientific reports
Apr 1, 2025
The major prevalent primary bone cancer is osteosarcoma. Preoperative chemotherapy is accompanied by resection as part of the normal course of treatment. The diagnosis and treatment of patients are based on the chemotherapy reaction. Contrarily, chem...
Identification of the shared gene signatures in retinoblastoma and osteosarcoma by machine learning.
Scientific reports
Dec 28, 2024
Osteosarcoma (OS) is the most prevalent secondary sarcoma associated with retinoblastoma (RB). However, the molecular mechanisms driving the interactions between these two diseases remain incompletely understood. This study aims to explore the transc...
Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression.
Frontiers in immunology
Dec 17, 2024
INTRODUCTION: Osteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses. A greater understanding of the t...
Protein Serine-Threonine Kinases
Tumor Microenvironment
Humans
Biomarkers, Tumor
Osteosarcoma
Machine Learning
Cell Line, Tumor
Male
Prognosis
Bone Neoplasms
Disease Progression
Gene Expression Regulation, Neoplastic
Protein-Tyrosine Kinases
Female
Cell Proliferation
DNA Copy Number Variations
Lymphocytes, Tumor-Infiltrating
Assessment of Artificial Intelligence Chatbot Responses to Common Patient Questions on Bone Sarcoma.
Journal of surgical oncology
Oct 29, 2024
BACKGROUND AND OBJECTIVES: The potential impacts of artificial intelligence (AI) chatbots on care for patients with bone sarcoma is poorly understood. Elucidating potential risks and benefits would allow surgeons to define appropriate roles for these...
High-quality expert annotations enhance artificial intelligence model accuracy for osteosarcoma X-ray diagnosis.
Cancer science
Sep 2, 2024
Primary malignant bone tumors, such as osteosarcoma, significantly affect the pediatric and young adult populations, necessitating early diagnosis for effective treatment. This study developed a high-performance artificial intelligence (AI) model to ...
Development and experimental validation of hypoxia-related gene signatures for osteosarcoma diagnosis and prognosis based on WGCNA and machine learning.
Scientific reports
Aug 12, 2024
Osteosarcoma (OS) is the most common primary malignant tumour of the bone with high mortality. Here, we comprehensively analysed the hypoxia signalling in OS and further constructed novel hypoxia-related gene signatures for OS prediction and prognosi...
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