AIMC Topic: Osteosarcoma
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LncRNAs regulates cell death in osteosarcoma.
Scientific reports
Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Prediction of High-Dose Methotrexate Blood Concentration in Osteosarcoma Patients Using Machine Learning.
Drug design, development and therapy
May 3, 2025
INTRODUCTION: High-dose methotrexate is a typical chemotherapy that is widely used in the treatment of osteosarcoma. However, the unique dose-response relationship of methotrexate makes its treatment window relatively narrow, and its clinical use is ...
Improved gated recurrent unit-based osteosarcoma prediction on histology images: a meta-heuristic-oriented optimization concept.
Scientific reports
Apr 1, 2025
The major prevalent primary bone cancer is osteosarcoma. Preoperative chemotherapy is accompanied by resection as part of the normal course of treatment. The diagnosis and treatment of patients are based on the chemotherapy reaction. Contrarily, chem...
Identification of the shared gene signatures in retinoblastoma and osteosarcoma by machine learning.
Scientific reports
Dec 28, 2024
Osteosarcoma (OS) is the most prevalent secondary sarcoma associated with retinoblastoma (RB). However, the molecular mechanisms driving the interactions between these two diseases remain incompletely understood. This study aims to explore the transc...
Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression.
Frontiers in immunology
Dec 17, 2024
INTRODUCTION: Osteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses. A greater understanding of the t...
Protein Serine-Threonine Kinases
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Humans
Tumor Microenvironment
Cell Proliferation
Osteosarcoma
Machine Learning
Lymphocytes, Tumor-Infiltrating
Bone Neoplasms
Biomarkers, Tumor
Prognosis
Protein-Tyrosine Kinases
Male
Female
DNA Copy Number Variations
Disease Progression
Assessment of Artificial Intelligence Chatbot Responses to Common Patient Questions on Bone Sarcoma.
Journal of surgical oncology
Oct 29, 2024
BACKGROUND AND OBJECTIVES: The potential impacts of artificial intelligence (AI) chatbots on care for patients with bone sarcoma is poorly understood. Elucidating potential risks and benefits would allow surgeons to define appropriate roles for these...
High-quality expert annotations enhance artificial intelligence model accuracy for osteosarcoma X-ray diagnosis.
Cancer science
Sep 2, 2024
Primary malignant bone tumors, such as osteosarcoma, significantly affect the pediatric and young adult populations, necessitating early diagnosis for effective treatment. This study developed a high-performance artificial intelligence (AI) model to ...
Development and experimental validation of hypoxia-related gene signatures for osteosarcoma diagnosis and prognosis based on WGCNA and machine learning.
Scientific reports
Aug 12, 2024
Osteosarcoma (OS) is the most common primary malignant tumour of the bone with high mortality. Here, we comprehensively analysed the hypoxia signalling in OS and further constructed novel hypoxia-related gene signatures for OS prediction and prognosi...
Machine learning and experimental analyses identified miRNA expression models associated with metastatic osteosarcoma.
Biochimica et biophysica acta. Molecular basis of disease
Jul 20, 2024
Osteosarcoma (OS), as the most common primary bone cancer, has a high invasiveness and metastatic potential, therefore, it has a poor prognosis. This study identified early diagnostic biomarkers using miRNA expression profiles associated with osteosa...
Machine learning survival prediction using tumor lipid metabolism genes for osteosarcoma.
Scientific reports
Jun 5, 2024
Osteosarcoma is a primary malignant tumor that commonly affects children and adolescents, with a poor prognosis. The existence of tumor heterogeneity leads to different molecular subtypes and survival outcomes. Recently, lipid metabolism has been ide...
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