Deep learning using histological images for gene mutation prediction in lung cancer: a multicentre retrospective study.

Journal: The Lancet. Oncology
PMID:

Abstract

BACKGROUND: Accurate detection of driver gene mutations is crucial for treatment planning and predicting prognosis for patients with lung cancer. Conventional genomic testing requires high-quality tissue samples and is time-consuming and resource-consuming, and as a result, is not available for most patients, especially those in low-resource settings. We aimed to develop an annotation-free Deep learning-enabled artificial intelligence method to predict GEne Mutations (DeepGEM) from routinely acquired histological slides.

Authors

  • Yu Zhao
    College of Agriculture, Shanxi Agricultural University, Taigu, Shanxi, China.
  • Shan Xiong
    Shandong Academy of Medical Sciences, Institute of Materia Medica, Ji'nan 250062, People's Republic of China.
  • Qin Ren
    AI Lab, Tencent, Shenzhen, China.
  • Jun Wang
    Department of Speech, Language, and Hearing Sciences and the Department of Neurology, The University of Texas at Austin, Austin, TX 78712, USA.
  • Min Li
    Hubei Provincial Institute for Food Supervision and Test, Hubei Provincial Engineering and Technology Research Center for Food Quality and Safety Test, Wuhan 430075, China.
  • Lin Yang
    National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Di Wu
    University of Melbourne, Melbourne, VIC 3010 Australia.
  • Kejing Tang
    Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Xiaojie Pan
    Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
  • Fengxia Chen
    Department of Thoracic Surgery, Hainan General Hospital, Haikou, China.
  • Wenxiang Wang
    College of Mathematics and Informatics, South China Agricultural University, Guangzhou, 510000, China.
  • Shi Jin
    State Grid Hubei Electric Power Co., Ltd, Wuhan 430000, China.
  • Xianling Liu
    Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Gen Lin
    Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis, Fuzhou, China.
  • Wenxiu Yao
    Department of Chemotherapy, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, China.
  • Linbo Cai
    Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
  • Yi Yang
    Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Jixian Liu
    Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
  • Jingxun Wu
    Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Wenfan Fu
    Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
  • Kai Sun
    Department of Materials Science and Engineering, Jinan University.
  • Feng Li
    Department of General Surgery, Shanghai Traditional Chinese Medicine (TCM)-INTEGRATED Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Bo Cheng
    Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Shuting Zhan
    Department of Thoracic Oncology and Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Haixuan Wang
    Department of Thoracic Oncology and Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Ziwen Yu
    Department of Thoracic Oncology and Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Xiwen Liu
    Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Ran Zhong
    Collaborative & Innovation Center, Central China Normal University, Wuhan, Hubei, China.
  • Huiting Wang
    Department of Thoracic Oncology and Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Ping He
    Shanghai Hospital Development Center, Shanghai 200040, China. Electronic address: heping@shdc.org.cn.
  • Yongmei Zheng
    Department of Thoracic Oncology and Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Peng Liang
    Yantaishan Hospital, Yantai City, Shandong Province, 264001, People's Republic of China.
  • Longfei Chen
    College of Electromechanical Engineering, Qingdao University of Science and Technology, Qingdao, China.
  • Ting Hou
  • Junzhou Huang
  • Bing He
    School of Business, Jiangsu Ocean University, Haizhou District, Lianyungang, Jiangsu, China.
  • Jiangning Song
    College of Information Engineering, Northwest A&F University, Yangling 712100, China, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia, National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, Centre for Research in Intelligent Systems, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia and ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia College of Information Engineering, Northwest A&F University, Yangling 712100, China, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia, National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, Centre for Research in Intelligent Systems, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia and ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia College of Information Engineering, Northwest A&F University, Yangling 712100, China, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia, National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, Centre for Research in Intelligent Systems, Faculty of Information Technology, Monash University, Melbourne, VIC 3800, Australia and ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, VIC 3800, Australia.
  • Lin Wu
    Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University Chengdu 610039 China xingyage1@163.com.
  • Chengping Hu
    Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China.
  • Jianxing He
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
  • Jianhua Yao
  • Wenhua Liang
    Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.