Development and Validation of a Deep Learning System to Differentiate HER2-Zero, HER2-Low, and HER2-Positive Breast Cancer Based on Dynamic Contrast-Enhanced MRI.

Journal: Journal of magnetic resonance imaging : JMRI
PMID:

Abstract

BACKGROUND: Previous studies explored MRI-based radiomic features for differentiating between human epidermal growth factor receptor 2 (HER2)-zero, HER2-low, and HER2-positive breast cancer, but deep learning's effectiveness is uncertain.

Authors

  • Yi Dai
    Department of Computer Science, University of California, Irvine, CA 92617, USA.
  • Chun Lian
    Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
  • Zhuo Zhang
  • Jing Gao
    Department of Gastroenterology 3, Hubei University of Medicine, Renmin Hospital, Shiyan, Hubei, China.
  • Fan Lin
    Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ziyin Li
    Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Qi Wang
    Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Tongpeng Chu
    Department of Radiology,Yantai Yuhuangding Hospital, Yantai, Shandong 264000 China; Big Data and Artificial Intelligence Lab, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China.
  • Dilinuer Aishanjiang
    Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
  • Meiying Chen
    Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
  • Ximing Wang
  • Guanxun Cheng
    Peking University Shenzhen Hospital, Peking University, Shenzhen, Guangdong, People's Republic of China.
  • Rong Huang
    School of Nursing, Chuanbei Medical College, Nanchong, China.
  • Jianjun Dong
    International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China. wangz@cust.edu.cn.
  • Haicheng Zhang
    Department of Radiology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, Shandong, People's Republic of China.
  • Ning Mao
    Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, People's Republic of China.