Predicting chemotherapy responsiveness in gastric cancer through machine learning analysis of genome, immune, and neutrophil signatures.

Journal: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
PMID: 39621213

Abstract

BACKGROUND: Gastric cancer is a major oncological challenge, ranking highly among causes of cancer-related mortality worldwide. This study was initiated to address the variability in patient responses to combination chemotherapy, highlighting the need for personalized treatment strategies based on genomic data.

Authors

  • Shota Sasagawa
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Yoshitaka Honma
    Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Xinxin Peng
    Precision Scientific (Beijing) Ltd, Beijing, 100085, China.
  • Kazuhiro Maejima
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Koji Nagaoka
    Department of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Yukari Kobayashi
    Department of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Ayako Oosawa
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Todd A Johnson
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Yuki Okawa
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Han Liang
    Department of Gastric Surgery, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.
  • Kazuhiro Kakimi
    Department of Immunotherapeutics, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 1130033, Japan.
  • Yasuhide Yamada
    Department of Medical Research, National Center for Global Health and Medicine, Tokyo, Japan.
  • Hidewaki Nakagawa
    Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. hidewaki@riken.jp.

Keywords

External Resources

Popular Topics
Recent Journals