Detecting B-cell lymphoma-6 overexpression status in primary central nervous system lymphoma using multiparametric MRI-based machine learning.

Journal: Neuroradiology
PMID: 39853344

Abstract

PURPOSE: In primary central nervous system lymphoma (PCNSL), B-cell lymphoma-6 (BCL-6) is an unfavorable prognostic biomarker. We aim to non-invasively detect BCL-6 overexpression in PCNSL patients using multiparametric MRI and machine learning techniques.

Authors

  • Mingxiao Wang
    Medical School of Chinese PLA, No.28 Fuxing Road, Haidian District, Beijing, 100853, China.
  • Guoli Liu
    School of Electronic & Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
  • Nan Zhang
    Department of Pulmonary and Critical Care Medicine II, Emergency General Hospital, Beijing, China.
  • Yanhua Li
    Department of Foreign Languages, Shanxi Medical University, Taiyuan, Shanxi, China.
  • Shuo Sun
    Laboratory of Biological Psychology, Department of Brain and Cognition, Leuven Brain Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Yahong Tan
    State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
  • Lin Ma
    Department of Radiation Oncology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.

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