Integrated multi-omics analysis identifies a machine learning-derived signature for predicting prognosis and therapeutic vulnerability in clear cell renal cell carcinoma.

Journal: Life sciences
PMID:

Abstract

AIMS: Clear cell renal cell carcinoma (ccRCC) shows considerable variation within and between tumors, presents varying treatment responses among patients, possibly due to molecular distinctions. This study utilized a multi-center and multi-omics analysis to establish and validate a prognosis and treatment vulnerability signature (PTVS) capable of effectively predicting patient prognosis and drug responsiveness.

Authors

  • Shengqiang Chi
    Engineering Research Center of EMR and Intelligent Expert System, Ministry of Education, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou Zhejiang Province, China.
  • Jing Ma
    Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
  • Yiming Ding
    From the Department of Radiology and Biomedical Imaging (Y.D., J.H.S., H.T., R.H., N.W.J., T.P.C., M.S.A., C.M.A., S.C.B., R.R.F., S.Y.H., Y.S., R.A.H., M.H.P., B.L.F.) and Institute for Computational Health Sciences (J.H.S., M.G.K., H.T., D.L., K.A.Z., D.H.), University of California, San Francisco, 550 Parnassus Ave, San Francisco, CA 94143; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, Calif (Y.D.); and Department of Radiology, University of California, Davis, Sacramento, Calif (L.N.).
  • Zeyi Lu
    Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
  • Zhenwei Zhou
    Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
  • Mingchao Wang
    Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
  • Gonghui Li
    Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, China. 3193119@zju.edu.cn.
  • Yuanlei Chen
    Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. Electronic address: yuanlei0926@zju.edu.cn.