Recent advancements of Raman spectroscopy application in topical products.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Published Date: Jul 1, 2025

Abstract

Topical products have gained popularity in the recent years. Diverse formulation types, complex composition, and thermodynamically instable nature present great challenges in the formulation development of topical products. The analytical methods available for topical formulation analysis and quality control are limited. To improve formulation development of various topical products, especially when API is suspended as a crystalline form in the formulation or recrystallizes during application, methods for topical formulation performance analysis and evaluation are of vital importance. In this article, we review advancements in applying Raman spectroscopy to the characterization and evaluation of topical product performance. Furthermore, the potential application of artificial intelligence combined with Raman spectroscopy in enhancing topical formulation development in the future will be presented.

Authors

  • Jing Pan
    College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
  • Xiaowei Liu
    Greater Bay Area Center for Drug Evaluation and Inspection of National Medical Products Administration, Shenzhen 518017, China.
  • Haiwu Yang
    Nycrist Pharmatech Limited, 2/2D, A3, Science and Technology Park, 3009 Guanguang Rd, Guangming, Shenzhen, Guangdong 518107, China.
  • Xiufeng Xu
    Nycrist Pharmatech Limited, 2/2D, A3, Science and Technology Park, 3009 Guanguang Rd, Guangming, Shenzhen, Guangdong 518107, China.
  • Fang Tian
    Department of Outpatient, Western Theater Command General Hospital of PLA, Chengdu, Sichuan, China.
  • Keith C Gordon
    Dodd-Walls Centre, Department of Chemistry, University of Otago, PO Box56, Dunedin 9054, New Zealand.
  • Cushla M McGoverin
    Nycrist Pharmatech Limited, 2/2D, A3, Science and Technology Park, 3009 Guanguang Rd, Guangming, Shenzhen, Guangdong 518107, China. Electronic address: cushla@nycrist.com.
  • Xiaolong Huang
    Greater Bay Area Center for Drug Evaluation and Inspection of National Medical Products Administration, Shenzhen 518017, China.

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