PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation.

Journal: BMC cancer
PMID:

Abstract

BACKGROUND: Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great significance. In our previous study, we found that prenylated rab acceptor 1 domain family member 2 (PRAF2) is an oncogene in BC. However, the exact mechanism of PRAF2 in BC cancer promotion is still not fully understood.

Authors

  • Zheng Wang
    Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Zilin Bi
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Hongguang Bo
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Junyi Xu
    School of Basic Medical Science, Capital Medical University, No. 10 Right Outside the Western Headlines, Beijing, 100069, China.
  • Rui Sha
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Zhaocai Yin
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Changsheng Yu
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Yufa Xu
    Department of Thyroid and Breast Surgery, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Zheshan West Rd No. 2, Wuhu , Anhui Province, 241001, China.
  • Xiaomeng Shi
    From the Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China (B.J., N.L., X.X.); CT Imaging Research Center, GE Healthcare China, Shanghai, China (X.S., S.Z., J.L.); and Departments of Epidemiology (G.H.d.B.) and Radiology (R.V.), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Wenbo Song
    School of Computer Science and Engineering, Hubei Key Laboratory of Intelligent Robot, Wuhan Institute of Technology, Wuhan, People's Republic of China.
  • Bin Chen
    Department of Otorhinolaryngology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
  • Yabing Wang
    School of Computer Science and Information Security, Guilin University of Electronic Technology, Guilin, Guangxi 541004, China.
  • Qian Zhang
    The Neonatal Intensive Care Unit, Peking Union Medical College Hospital, Peking, China.
  • Jianping Chen
    School of Earth Sciences and Resources, China University of Geosciences (Beijing), Beijing 100083, China.