Bulk integrated single-cell-spatial transcriptomics reveals the impact of preoperative chemotherapy on cancer-associated fibroblasts and tumor cells in colorectal cancer, and construction of related predictive models using machine learning.

Abstract

Authors

• Shangshang Hu
  School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China.
• Jian Qin
  College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
• Muzi Ding
  School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
• Rui Gao
  School of Control Science and Engineering, Shandong University, Jinan, China.
• Qianni Xiao
  School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
• Jinwei Lou
  School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
• Yuhan Chen
  Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
• Shukui Wang
  School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China. sk_wang@njmu.edu.cn.
• Yuqin Pan
  General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, No. 68, Changle Road, 210006, Nanjing, Jiangsu, China. panyuqin01@163.com.

Keywords

External Resources