AIMC Topic: Epithelial Cells
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Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.
Experimental eye research
May 23, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell.
Respiratory research
Apr 23, 2025
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, resulting in inconsistent findings across studies. Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient variability, i...
Multimodal feature fusion machine learning for predicting chronic injury induced by engineered nanomaterials.
Nature communications
Mar 20, 2025
Concerns regarding chronic injuries (e.g., fibrosis and carcinogenesis) induced by nanoparticles raised public health concerns and need to be rapidly assessed in hazard identification. Although in silico analysis is commonly used for risk assessment ...
Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.
Cells
Dec 26, 2024
The development of noninvasive methods for bladder cancer identification remains a critical clinical need. Recent studies have shown that atomic force microscopy (AFM), combined with pattern recognition machine learning, can detect bladder cancer by ...
Preparation, characterization, and protective effects of carbon dots against oxidative damage induced by LPS in IPEC-J2 cells.
Frontiers in cellular and infection microbiology
Dec 18, 2024
This study aimed to prepare carbon dots (GF-CDs) and examine their efficacy in mitigating oxidative stress and apoptosis in intestinal porcine epithelial cells from the jejunum (IPEC-J2 cells) induced by lipopolysaccharide (LPS). The GF-CDs were syn...
A novel AI-based score for assessing the prognostic value of intra-epithelial lymphocytes in oral epithelial dysplasia.
British journal of cancer
Nov 30, 2024
BACKGROUND: Oral epithelial dysplasia (OED) poses a significant clinical challenge due to its potential for malignant transformation and the lack of reliable prognostic markers. Current OED grading systems do not reliably predict transformation and s...
Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD.
JCI insight
Nov 8, 2024
Transcriptomic analyses have advanced the understanding of complex disease pathophysiology including chronic obstructive pulmonary disease (COPD). However, identifying relevant biologic causative factors has been limited by the integration of high di...
Bulk integrated single-cell-spatial transcriptomics reveals the impact of preoperative chemotherapy on cancer-associated fibroblasts and tumor cells in colorectal cancer, and construction of related predictive models using machine learning.
Biochimica et biophysica acta. Molecular basis of disease
Oct 5, 2024
BACKGROUND: Preoperative chemotherapy (PC) is an important component of Colorectal cancer (CRC) treatment, but its effects on the biological functions of fibroblasts and epithelial cells in CRC are unclear.
ReBiA-Robotic Enabled Biological Automation: 3D Epithelial Tissue Production.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 26, 2024
The Food and Drug Administration's recent decision to eliminate mandatory animal testing for drug approval marks a significant shift to alternative methods. Similarly, the European Parliament is advocating for a faster transition, reflecting public p...
Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair.
eLife
Sep 23, 2024
Cell division is fundamental to all healthy tissue growth, as well as being rate-limiting in the tissue repair response to wounding and during cancer progression. However, the role that cell divisions play in tissue growth is a collective one, requir...
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