Step Width Estimation in Individuals With and Without Neurodegenerative Disease via a Novel Data-Augmentation Deep Learning Model and Minimal Wearable Inertial Sensors.
Journal:
IEEE journal of biomedical and health informatics
PMID:
39331558
Abstract
Step width is vital for gait stability, postural balance control, and fall risk reduction. However, estimating step width typically requires either fixed cameras or a full kinematic body suit of wearable inertial measurement units (IMUs), both of which are often too expensive and time-consuming for clinical application. We thus propose a novel data-augmented deep learning model for estimating step width in individuals with and without neurodegenerative disease using a minimal set of wearable IMUs. Twelve patients with neurodegenerative, clinically diagnosed Spinocerebellar ataxia type 3 (SCA3) performed over ground walking trials, and seventeen healthy individuals performed treadmill walking trials at various speeds and gait modifications while wearing IMUs on each shank and the pelvis. Results demonstrated step width mean absolute errors of 3.3 0.7 cm and 2.9 0.5 cm for the neurodegenerative and healthy groups, respectively, which were below the minimal clinically important difference of 6.0 cm. Step width variability mean absolute errors were 1.5 cm and 0.8 cm for neurodegenerative and healthy groups, respectively. Data augmentation significantly improved accuracy performance in the neurodegenerative group, likely because they exhibited larger variations in walking kinematics as compared with healthy subjects. These results could enable clinically meaningful and accurate portable step width monitoring for individuals with and without neurodegenerative disease, potentially enhancing rehabilitative training, assessment, and dynamic balance control in clinical and real-life settings.