Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation.

Journal: Breast cancer research : BCR
PMID:

Abstract

BACKGROUND: Tumour vascular density assessed from CD-31 immunohistochemistry (IHC) images has previously been shown to have prognostic value in breast cancer. Current methods to measure vascular density, however, are time-consuming, suffer from high inter-observer variability and are limited in describing the complex tumour vasculature morphometry.

Authors

  • Tristan Whitmarsh
    Department of Astronomy, University of Cambridge, Cambridge, UK.
  • Wei Cope
    Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Julia Carmona-Bozo
    School of Medicine, University of California San Francisco, San Francisco, US.
  • Roido Manavaki
    Department of Radiology, University of Cambridge, Cambridge, UK.
  • Stephen-John Sammut
    Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
  • Ramona Woitek
    Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK; Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna 1090, Austria. Electronic address: rw585@cam.ac.uk.
  • Elena Provenzano
    Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Emma L Brown
    Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
  • Sarah E Bohndiek
    Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
  • Ferdia A Gallagher
  • Carlos Caldas
    Cancer Research UK Cambridge Centre, University of Cambridge, CB2 0RE Cambridge, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, United Kingdom; Department of Oncology, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service (NHS) Foundation Trust, CB2 0QQ Cambridge, United Kingdom.
  • Fiona J Gilbert
    Department of Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Center, Cambridge, United Kingdom.
  • Florian Markowetz
    Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK. Electronic address: florian.markowetz@cruk.cam.ac.uk.