Transcriptional regulation of hypoxic cancer cell metabolism and artificial intelligence.

Journal: Trends in cancer
PMID: 39482194

Abstract

Gene expression regulation in hypoxic tumor microenvironments is mediated by O responsive transcription factors (OR-TFs), fine-tuning cancer cell metabolic demand for O according to its availability. Here, we discuss key OR-TFs and emerging artificial intelligence (AI)-based applications suitable for the interrogation of OR-TF relationships specifying cancer cell metabolic adaptations to hypoxia.

Authors

  • Luana Schito
    School of Medicine, University College Dublin, Belfield, Dublin 4, D04 C7X2, Ireland; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, D04 C7X2, Ireland. Electronic address: luana.schito@ucd.ie.
  • Sergio Rey-Keim
    School of Medicine, University College Dublin, Belfield, Dublin 4, D04 C7X2, Ireland; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, D04 C7X2, Ireland. Electronic address: sergio.rey@ucd.ie.

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