AIMC Topic: Cell Hypoxia

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine May 9, 2025
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
Humans Biomarkers Female Middle Aged Case-Control Studies ROC Curve Aged Male Myocytes, Smooth Muscle Guanine Nucleotide Exchange Factors Foam Cells Coronary Artery Disease Cell Hypoxia
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Transcriptional regulation of hypoxic cancer cell metabolism and artificial intelligence.

Trends in cancer Oct 30, 2024
Gene expression regulation in hypoxic tumor microenvironments is mediated by O responsive transcription factors (OR-TFs), fine-tuning cancer cell metabolic demand for O according to its availability. Here, we discuss key OR-TFs and emerging artificia...
Artificial Intelligence Tumor Microenvironment Neoplasms Humans Oxygen Cell Hypoxia Tumor Hypoxia Gene Expression Regulation, Neoplastic Transcription Factors
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Exploring machine learning for untargeted metabolomics using molecular fingerprints.

Computer methods and programs in biomedicine Apr 8, 2024
BACKGROUND: Metabolomics, the study of substrates and products of cellular metabolism, offers valuable insights into an organism's state under specific conditions and has the potential to revolutionise preventive healthcare and pharmaceutical researc...
Ataxia Telangiectasia Humans Machine Learning Cell Line Cell Hypoxia Metabolomics
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A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells.

Analytica chimica acta Dec 24, 2019
Development of a mitochondria-targeting fluorescent probe with large Stokes shift and long-wavelength emission was benefit for accurate detection of hypoxic status, which was known as a major factor of the tumor physiology and influence important pat...
Pyridinium Compounds Quinolinium Compounds Cell Hypoxia Nitroreductases Cell Line, Tumor Spectrometry, Fluorescence Protein Binding Microscopy, Fluorescence Mitochondria Humans Fluorescent Dyes Limit of Detection Molecular Docking Simulation Benzothiazoles
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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Gemcitabine Misonidazole Cell Hypoxia Fluorine Radioisotopes Antimetabolites, Antineoplastic Deoxycytidine Benzimidazoles Quinolones Neovascularization, Pathologic Pancreas Breast Positron-Emission Tomography Cell Line, Tumor Mice Mice, Nude Humans Angiogenesis Inhibitors Pancreatic Neoplasms Breast Neoplasms Animals Female
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[Y-27632 protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy pathway].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Nov 1, 2017
Objective To investigate the protective effect of preconditioning with Rho-kinase inhibitor Y-27632 on H9c2 cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and explore its underlying mechanism. Methods H9c2 cardiomyocytes were divided into...
Autophagy Myocytes, Cardiac L-Lactate Dehydrogenase Cell Hypoxia Beclin-1 Amides Phosphorylation Oxygen Apoptosis Protective Agents Cell Line Animals Myosin Light Chains Pyridines Cell Survival Rats Signal Transduction
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