Circulating lncRNAs as biomarkers for severe dengue using a machine learning approach.

Journal: The Journal of infection
PMID: 40090592

Abstract

OBJECTIVES: Dengue virus (DENV) infection is a significant global health concern, causing severe morbidity and mortality. While many cases present as a mild febrile illness, some progress to life-threatening severe dengue (SD). Early intervention is essential to improve outcomes, but current predictive methods lack specificity, burdening healthcare systems in endemic regions. Circulating long non-coding RNAs (lncRNAs) have emerged as stable and promising biomarkers. This study explored the use of lncRNAs as predictive markers for SD.

Authors

  • Rodolfo Katz
    Department of Clinical Microbiology and Immunology, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Nguyen Minh Nam
    103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
  • Tulio de Lima Campos
    Bioinformatics Core Facility, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife PE, Brazil.
  • Victoria Indenbaum
    Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel.
  • Sophie Terenteva
    Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel.
  • Dinh Thi Thu Hang
    Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
  • Le Thi Hoi
  • Amos Danielli
    Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel.
  • Yaniv Lustig
    Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel; School of Public Health, School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Eli Schwartz
    The Institute of Tropical Medicine, Sheba Medical Center, Ramat Gan, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Hoang Van Tong
    Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.
  • Ella H Sklan
    Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Keywords

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