PLSKB: An Interactive Knowledge Base to Support Diagnosis, Treatment, and Screening of Lynch Syndrome on the Basis of Precision Oncology.

Journal: JCO clinical cancer informatics
PMID: 40085801

Abstract

PURPOSE: Understanding the genetic heterogeneity of Lynch syndrome (LS) cancers has led to significant scientific advancements. However, these findings are widely dispersed across various resources, making it difficult for clinicians and researchers to stay informed. Furthermore, the uneven quality of studies and the lack of effective translation of knowledge into clinical practice create challenges in delivering optimal patient care. To address these issues, we developed and launched the Precision Lynch Syndrome Knowledge Base (PLSKB), a specialized, interactive web-based platform that consolidates comprehensive information on LS.

Authors

  • Mahsa Dehghani Soufi
    Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Reza Shirkoohi
    Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Zohreh Sanaat
    Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Anna Torkamannia
    Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Meysam Hashemi
    Aix Marseille University INSERM, INS, Institute for Systems Neuroscience, 13005 Marseille, France meysam.hashemi@univ-amu.fr.
  • Samaneh Jahandar-Lashaki
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mahsa Yousefpour Marzbali
    Research Center for Immunodeficiency, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Yosra Vaez
    Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Reza Ferdousi
    Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.

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