Machine learning for the rElapse risk eValuation in acute biliary pancreatitis: The deep learning MINERVA study protocol.

Journal: World journal of emergency surgery : WJES
PMID: 40033414

Abstract

BACKGROUND: Mild acute biliary pancreatitis (MABP) presents significant clinical and economic challenges due to its potential for relapse. Current guidelines advocate for early cholecystectomy (EC) during the same hospital admission to prevent recurrent acute pancreatitis (RAP). Despite these recommendations, implementation in clinical practice varies, highlighting the need for reliable and accessible predictive tools. The MINERVA study aims to develop and validate a machine learning (ML) model to predict the risk of RAP (at 30, 60, 90 days, and at 1-year) in MABP patients, enhancing decision-making processes.

Authors

  • Mauro Podda
    Department of Surgical Science, University of Cagliari, Cagliari, Italy. Electronic address: mauropodda@ymail.com.
  • Adolfo Pisanu
    Department of Surgical Science, University of Cagliari, Cagliari, Italy. Electronic address: adolfo.pisanu@unica.it.
  • Gianluca Pellino
    Colorectal Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Adriano De Simone
    Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Lucio Selvaggi
    Department of Advanced Medical and Surgical Sciences, Università Degli Studi Della Campania "Luigi Vanvitelli", Naples, Italy.
  • Valentina Murzi
    Department of Surgical Science, Emergency Surgery Unit, University of Cagliari, Cagliari, Italy.
  • Eleonora Locci
    Department of Surgical Science, Emergency Surgery Unit, University of Cagliari, Cagliari, Italy.
  • Matteo Rottoli
    Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Giacomo Calini
    Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Stefano Cardelli
    Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Fausto Catena
    Department of General and Emergency Surgery, Bufalini Hospital-Level 1 Trauma Center, Cesena, Italy.
  • Carlo Vallicelli
    Department of General and Emergency Surgery, Bufalini Hospital-Level 1 Trauma Center, Cesena, Italy.
  • Raffaele Bova
    Department of General and Emergency Surgery, Bufalini Hospital-Level 1 Trauma Center, Cesena, Italy.
  • Gabriele Vigutto
    Department of General and Emergency Surgery, Bufalini Hospital-Level 1 Trauma Center, Cesena, Italy.
  • Fabrizio D'Acapito
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Forlì, Italy.
  • Giorgio Ercolani
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Forlì, Italy.
  • Leonardo Solaini
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Forlì, Italy.
  • Alan Biloslavo
    General Surgery Department, Trieste University Hospital, Trieste, Italy.
  • Paola Germani
    General Surgery Department, Trieste University Hospital, Trieste, Italy.
  • Camilla Colutta
    General Surgery Department, Trieste University Hospital, Trieste, Italy.
  • Savino Occhionorelli
    Emergency Surgery Department, Ferrara University Hospital, Ferrara, Italy.
  • Domenico Lacavalla
    Emergency Surgery Department, Ferrara University Hospital, Ferrara, Italy.
  • Maria Grazia Sibilla
    Emergency Surgery Department, Ferrara University Hospital, Ferrara, Italy.
  • Stefano Olmi
    Università Vita-Salute San Raffaele, Milan, Italy.
  • Matteo Uccelli
    Department of General and Oncological Surgery, Minimally Invasive Surgery Center, San Marco Hospital GSD, Bergamo, Zingonia, Italy.
  • Alberto Oldani
    Department of General and Oncological Surgery, Minimally Invasive Surgery Center, San Marco Hospital GSD, Bergamo, Zingonia, Italy.
  • Alessio Giordano
    Unit of Emergency Surgery, Careggi University Hospital, Florence, Italy.
  • Tommaso Guagni
    Unit of Emergency Surgery, Careggi University Hospital, Florence, Italy.
  • Davina Perini
    Unit of Emergency Surgery, Careggi University Hospital, Florence, Italy.
  • Francesco Pata
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036, Italy.
  • Bruno Nardo
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036, Italy.
  • Daniele Paglione
    Azienda Ospedaliera Annunziata, Cosenza, Italy.
  • Giusi Franco
    Azienda Ospedaliera Annunziata, Cosenza, Italy.
  • Matteo Donadon
    Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; Department of General Surgery, University Maggiore Hospital Della Carità, Novara, Italy.
  • Marcello Di Martino
    Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. Electronic address: marcello.dimartino@uniupo.it.
  • Dario Bruzzese
    Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Daniela Pacella
    Department of Public Health, University of Naples Federico II, Naples, Italy.

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