A Lightweight Deep Convolutional Neural Network Extracting Local and Global Contextual Features for the Classification of Alzheimer's Disease Using Structural MRI.

Recent advancements in the classification of Alzheimer's disease have leveraged the automatic feature generation capability of convolutional neural networks (CNNs) using neuroimaging biomarkers. However, most of the existing CNN-based methods often disregard the local features of the brain data, which leads to a loss of subtle fine-grained features in the brain imaging data. Moreover, the existing CNN architectures, which mainly rely on global features, do not pay much attention to the discriminability of the extracted features for the task of classification of Alzheimer's disease. Moreover, the existing architectures often end up using a large number of parameters to enhance the richness of the extracted features. This paper proposes a novel lightweight deep CNN, which extracts local and global contextual features from the sagittal slices of structural MRI data and uses both of these two types of features for the classification of the disease. The main idea used in designing the proposed network is to process separately the local and global features by using modules that pay a special attention to extract local and global contextual features. The fused local and global contextual features are then used for the classification of Alzheimer's disease. The proposed network is tested for the binary and multiclass classifications of the disease using the MR images taken from the ADNI database. The proposed network is shown to provide a performance that is significantly higher than that provided by other existing state-of-the-art networks, yet using a number of parameters that is a small fraction of that used by the other schemes.