DeepES: deep learning-based enzyme screening to identify orphan enzyme genes.
Journal:
Bioinformatics (Oxford, England)
PMID:
39909853
Abstract
MOTIVATION: Progress in sequencing technology has led to determination of large numbers of protein sequences, and large enzyme databases are now available. Although many computational tools for enzyme annotation were developed, sequence information is unavailable for many enzymes, known as orphan enzymes. These orphan enzymes hinder sequence similarity-based functional annotation, leading gaps in understanding the association between sequences and enzymatic reactions.