AIMC Topic: Multigene Family
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Regulation and induction of fungal secondary metabolites: a comprehensive review.
Archives of microbiology
Jul 1, 2025
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthe...
NLP-like deep learning aided in identification and validation of thiosulfinate tolerance clusters in diverse bacteria.
mSphere
Jun 17, 2025
Allicin tolerance () clusters in phytopathogenic bacteria, which provide resistance to thiosulfinates like allicin, are challenging to find using conventional approaches due to their varied architecture and the paradox of being vertically maintained ...
Machine learning uncovers the transcriptional regulatory network for the production host Streptomyces albidoflavus.
Cell reports
Mar 8, 2025
Streptomyces albidoflavus is a widely used strain for natural product discovery and production through heterologous biosynthetic gene clusters (BGCs). However, the transcriptional regulatory network (TRN) and its impact on secondary metabolism remain...
CSEL-BGC: A Bioinformatics Framework Integrating Machine Learning for Defining the Biosynthetic Evolutionary Landscape of Uncharacterized Antibacterial Natural Products.
Interdisciplinary sciences, computational life sciences
Sep 30, 2024
The sluggish pace of new antibacterial drug development reflects a vulnerability in the face of the current severe threat posed by bacterial resistance. Microbial natural products (NPs), as a reservoir of immense chemical potential, have emerged as t...
Machine-Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 12, 2024
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation. Therefore, a fundamental understanding of transcriptional ...
Deep Learning to Predict the Biosynthetic Gene Clusters in Bacterial Genomes.
Journal of molecular biology
May 6, 2022
Biosynthetic gene clusters (BGCs) in bacterial genomes code for important small molecules and secondary metabolites. Based on the validated BGCs and the corresponding sequences of protein family domains (Pfams), Pfam functions and clan information, w...
Microbial chassis engineering drives heterologous production of complex secondary metabolites.
Biotechnology advances
Apr 26, 2022
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently known secondary metabolites. Heterologous production of secondary metabolite BGCs in suitable chassis facilitates yield improvement and discovery of new-to-nat...
Profiling of 35 Cases of Hb S/Hb E (: c.20A>T/: c.79G>a), Disease and Association with α-Thalassemia and β-Globin Gene Cluster Haplotypes from Odisha, India.
Hemoglobin
Mar 4, 2022
Hb S/Hb E (: c.20A>T/: c.79G>A) is an uncommon variant of sickle cell disease resulting from coinheritance of Hb S and Hb E. Clinico-hematological and biochemical parameters of 35 cases of Hb S/Hb E disease were studied and compared with 70 matched c...
Development and validation of multiple machine learning algorithms for the classification of G-protein-coupled receptors using molecular evolution model-based feature extraction strategy.
Amino acids
Sep 25, 2021
Machine learning is one of the most potential ways to realize the function prediction of the incremental large-scale G-protein-coupled receptors (GPCR). Prior research reveals that the key to determining the overall classification accuracy of GPCR is...
HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.
Reproductive biology and endocrinology : RB&E
Sep 1, 2021
Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly b...
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