AIMC Topic: Multigene Family

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Regulation and induction of fungal secondary metabolites: a comprehensive review.

Archives of microbiology Jul 1, 2025
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthe...
Biosynthetic Pathways Secondary Metabolism Metabolic Engineering Fungi Multigene Family Gene Expression Regulation, Fungal
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Machine learning uncovers the transcriptional regulatory network for the production host Streptomyces albidoflavus.

Cell reports Mar 8, 2025
Streptomyces albidoflavus is a widely used strain for natural product discovery and production through heterologous biosynthetic gene clusters (BGCs). However, the transcriptional regulatory network (TRN) and its impact on secondary metabolism remain...
Streptomyces Multigene Family Gene Expression Regulation, Bacterial Transcriptome Gene Regulatory Networks Machine Learning
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CSEL-BGC: A Bioinformatics Framework Integrating Machine Learning for Defining the Biosynthetic Evolutionary Landscape of Uncharacterized Antibacterial Natural Products.

Interdisciplinary sciences, computational life sciences Sep 30, 2024
The sluggish pace of new antibacterial drug development reflects a vulnerability in the face of the current severe threat posed by bacterial resistance. Microbial natural products (NPs), as a reservoir of immense chemical potential, have emerged as t...
Computational Biology Biological Products Evolution, Molecular Multigene Family Machine Learning Genome, Bacterial Anti-Bacterial Agents Bacteria
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Machine-Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 12, 2024
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation. Therefore, a fundamental understanding of transcriptional ...
Gene Regulatory Networks Multigene Family Gene Expression Regulation, Bacterial Secondary Metabolism Streptomyces coelicolor Machine Learning Gene Expression Profiling Transcriptome
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Deep Learning to Predict the Biosynthetic Gene Clusters in Bacterial Genomes.

Journal of molecular biology May 6, 2022
Biosynthetic gene clusters (BGCs) in bacterial genomes code for important small molecules and secondary metabolites. Based on the validated BGCs and the corresponding sequences of protein family domains (Pfams), Pfam functions and clan information, w...
Multigene Family Biosynthetic Pathways Genome, Bacterial Deep Learning Bacteria
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Microbial chassis engineering drives heterologous production of complex secondary metabolites.

Biotechnology advances Apr 26, 2022
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently known secondary metabolites. Heterologous production of secondary metabolite BGCs in suitable chassis facilitates yield improvement and discovery of new-to-nat...
Polyketides Multigene Family Synthetic Biology Saccharomyces cerevisiae Metabolic Engineering Artificial Intelligence Escherichia coli
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Profiling of 35 Cases of Hb S/Hb E (: c.20A>T/: c.79G>a), Disease and Association with α-Thalassemia and β-Globin Gene Cluster Haplotypes from Odisha, India.

Hemoglobin Mar 4, 2022
Hb S/Hb E (: c.20A>T/: c.79G>A) is an uncommon variant of sickle cell disease resulting from coinheritance of Hb S and Hb E. Clinico-hematological and biochemical parameters of 35 cases of Hb S/Hb E disease were studied and compared with 70 matched c...
alpha-Thalassemia Humans beta-Globins Anemia, Sickle Cell beta-Thalassemia Haplotypes Multigene Family
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Development and validation of multiple machine learning algorithms for the classification of G-protein-coupled receptors using molecular evolution model-based feature extraction strategy.

Amino acids Sep 25, 2021
Machine learning is one of the most potential ways to realize the function prediction of the incremental large-scale G-protein-coupled receptors (GPCR). Prior research reveals that the key to determining the overall classification accuracy of GPCR is...
Algorithms Evolution, Molecular Receptors, G-Protein-Coupled Amino Acid Sequence Multigene Family Sequence Alignment Machine Learning
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HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.

Reproductive biology and endocrinology : RB&E Sep 1, 2021
Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly b...
Genes, Homeobox Gene Ontology Homeodomain Proteins Gene Regulatory Networks Young Adult Signal Transduction Humans Adult Transcription Factors Endometrium Female Gene Expression Profiling Endometriosis Multigene Family
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Prioritizing and characterizing functionally relevant genes across human tissues.

PLoS computational biology Jul 16, 2021
Knowledge of genes that are critical to a tissue's function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model-FUGUE-combini...
Neoplasms Transcriptome Genome-Wide Association Study Humans Computational Biology Tissue Distribution Machine Learning Female Models, Genetic Gene Expression Regulation, Developmental Software Multigene Family Male Transcription Factors Protein Interaction Maps Genome, Human Gene Regulatory Networks Genetic Association Studies
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