Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach.

Journal: BMC neurology
PMID: 40269737

Abstract

BACKGROUND: Vascular disease in aging populations spans a wide range of disorders including strokes, circulation disorders and hypertension. As individuals age, vascular disorders co-occur and hence exert combined effects. In the present study we introduce vascular-related biological stress as a novel biomarker to capture the combined effects of vascular disease burden for more precision in early detection of cognitive changes in aging.

Authors

  • Reem Waziry
    Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA. reemwaziry@gmail.com.
  • Olajide A Williams
    Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA.
  • Henning Tiemeier
    Department of Epidemiology and Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Caleb Miles
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA.

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