Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study.

Journal: BMC oral health
PMID: 40349046

Abstract

BACKGROUND: Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for dentin-pulp complex or whole pulp regeneration. This study aimed to evaluate the effect of DPCs-sEVs on the proliferation rate, migration capability, and expression pattern of DPCs for osteo/odontogenic gene markers in comparison with mineral trioxide aggregate (MTA).

Authors

  • Dina A Hammouda
    Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
  • Alaa M Mansour
    Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt. alaa_mamdouh@mans.edu.eg.
  • Ahmed R Zaher
    Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.
  • Mohammed E Grawish
    Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 35511, Egypt.

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