Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study.

Abstract

Authors

• Hamed Akbari
  Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia.
• Spyridon Bakas
  Perelman School of Medicine, Philadelphia, PA, USA.
• Chiharu Sako
  Center for Biomedical Image Computing and Analytics.
• Anahita Fathi Kazerooni
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Javier Villanueva-Meyer
  Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
• Jose A Garcia
  Center for Data Science and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Elizabeth Mamourian
  Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for and Data Science for Integrated Diagnostics (AID), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Fang Liu
  The First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.
• Quy Cao
  Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Russell T Shinohara
  Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for and Data Science for Integrated Diagnostics (AID), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Ujjwal Baid
  Perelman School of Medicine, Philadelphia, PA, USA.
• Alexander Getka
  Center for Data Science and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Sarthak Pati
  Perelman School of Medicine, Philadelphia, PA, USA.
• Ashish Singh
  Artificial Intelligence in Biomedical Imaging Lab, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Evan Calabrese
  Department of Radiology and Biomedical Imaging, University of California At San Francisco, 350 Parnassus Ave, Suite 307H, San Francisco, CA, 94143-0628, USA. evan.calabrese@ucsf.edu.
• Susan Chang
  Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
• Jeffrey Rudie
  Department of Radiology, University of California San Diego, San Diego, California, USA.
• Aristeidis Sotiras
  Department of Radiology and Institute of Informatics, Washington University in St. Luis, St. Luis, MO63110, USA.
• Pamela LaMontagne
  Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
• Daniel S Marcus
  Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
• Mikhail Milchenko
  Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
• Arash Nazeri
  From the Department of Bioengineering, Rice University, Houston, Tex (S. Fan); Department of Radiology (S. Fan, M.R.P., P.X., S.M.H., J.J.L., S. Flores, P.L., B.G., C.A.R., D.S.M., A.N., T.L.S.B., A.S.), Charles F. and Joanne Knight Alzheimer Disease Research Center (B.G., B.M.A., R.B., J.C.M., T.L.S.B.), Department of Neurology (C.A.R., B.M.A., R.J.B., J.C.M.), and Institute for Informatics, Data Science and Biostatistics (A.S.), Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8132, St Louis, MO 63110; Duke-NUS Medical School, Singapore (S. Fan); Department of Electrical and Systems Engineering, Washington University in St Louis, St Louis, Mo (S.C., A.S.); Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada (A.N.); and Tracy Family SILQ Center for Neurodegenerative Biology, St Louis, Mo (R.J.B.).
• Carmen Balana
  B-ARGO Group, Institut Investigació Germans Trias i Pujol (IGTP), Badalona (Barcelona), Catalonia, Spain.
• Jaume Capellades
  Research Unit (IDIR), Image Diagnosis Institute, Badalona, Spain.
• Josep Puig
  Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology (Girona Biomedical Research Institute) IDIBGI, Hospital Universitari Dr. Josep Trueta, 17007 Girona, Spain.
• Chaitra Badve
  Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA.
• Jill S Barnholtz-Sloan
  Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
• Andrew E Sloan
  Brain and Tumor Neurosurgery, Neurosurgical Oncology, Piedmont Health, Atlanta, Georgia, USA.
• Vachan Vadmal
  Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
• Kristin Waite
  Center for Biomedical Informatics and Information Technology (CBIIT), National Cancer Institute, Bethesda, Maryland, USA.
• Murat Ak
  Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
• Rivka R Colen
  Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Yae Won Park
  Department of Radiology, Ewha Womans University College of Medicine, Seoul, Korea.
• Sung Soo Ahn
  Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Center for Clinical Image Data Science, Yonsei University College of Medicine, Seoul, Korea. sungsoo@yuhs.ac.
• Jong Hee Chang
  Department of Neurosurgery, Yonsei University College of Medicine, Seoul, South Korea.
• Yoon Seong Choi
  Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.
• Seung-Koo Lee
  Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.
• Gregory S Alexander
  Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• Ayesha S Ali
  Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• Adam P Dicker
  Shivank Garg, Noelle L. Williams, and Adam P. Dicker, Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia, PA; and Andrew Ip, Winship Cancer Institute at Emory University, Atlanta, GA.
• Adam E Flanders
• Spencer Liem
  Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• Joseph Lombardo
  Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• Wenyin Shi
  Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• Gaurav Shukla
  Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania.
• Brent Griffith
  Department of Radiology, Henry Ford Hospital, Detroit, MI, USA.
• Laila M Poisson
  Department of Public Health Sciences, Center for Bioinformatics, Henry Ford Health System, Detroit, Michigan, USA.
• Lisa R Rogers
  Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan, USA.
• Aikaterini Kotrotsou
  MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
• Thomas C Booth
  School of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom.
• Rajan Jain
  1 Department of Radiology, New York University Langone Medical Center, 660 1st Ave, Rm 336, New York, NY 10016.
• Matthew Lee
  Department of Urology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
• Abhishek Mahajan
  Department of Imaging, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool L7 8YA, UK.
• Arnab Chakravarti
  Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
• Joshua D Palmer
  Department of Radiation Oncology, The James Cancer Hospital and Solove Research Institute at the Ohio State University, Columbus, Ohio.
• Dominic DiCostanzo
  Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
• Hassan Fathallah-Shaykh
  Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
• Santiago Cepeda
  Neurosurgery Department, Rio Hortega University Hospital, 47012 Valladolid, Spain.
• Orazio Santo Santonocito
  Division of Neurosurgery, Spedali Riuniti di Livorno-Azienda USL Toscana Nord-Ovest, Livorno, Italy.
• Anna Luisa Di Stefano
  Division of Neurosurgery, Spedali Riuniti di Livorno-Azienda USL Toscana Nord-Ovest, Livorno, Italy.
• Benedikt Wiestler
  Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675 Munich, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Germany.
• Elias R Melhem
  Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
• Graeme F Woodworth
  Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
• Pallavi Tiwari
  Department of Radiology, University of Wisconsin, Madison, WI, USA.
• Pablo Valdes
  Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
• Yuji Matsumoto
  Department of Applied Chemistry, School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan.
• Yoshihiro Otani
  Department of Neurological Surgery, Okayama University, Okayama, Japan.
• Ryoji Imoto
  Department of Neurological Surgery, Okayama University, Okayama, Japan.
• Mariam Aboian
  Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
• Shinichiro Koizumi
  Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
• Kazuhiko Kurozumi
  Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
• Toru Kawakatsu
  Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
• Kimberley Alexander
  Department of Neurosurgery, Chris O'Brien Lifehouse, Camperdown, Australia.
• Laveniya Satgunaseelan
  Department of Neurosurgery, Chris O'Brien Lifehouse, Camperdown, Australia.
• Aaron M Rulseh
  Department of Radiology, Na Homolce Hospital, Prague, Czechia.
• Stephen J Bagley
  Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
• Michel Bilello
  Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania.
• Zev A Binder
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Steven Brem
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
• Arati S Desai
  Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
• Robert A Lustig
  Department of Radiation-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Eileen Maloney
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Timothy Prior
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Nduka Amankulor
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• MacLean P Nasrallah
  Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
• Donald M O'Rourke
  Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
• Suyash Mohan
  Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (J.D.R., L.X., A.K., J.M.E., T.C., I.M.N., S.M., J.C.G.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (J.D.R., A.M.R.); Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, Pa (X.L., J.W.); University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (M.T.D.); Mecklenburg Radiology Associates, Charlotte, NC (E.J.B.); Department of Radiology, University of Texas, Austin, Tex (R.N.B.); and Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pa (I.M.N.).
• Christos Davatzikos
  Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for and Data Science for Integrated Diagnostics (AID), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Keywords

External Resources