AI-DBS study: protocol for a longitudinal prospective observational cohort study of patients with Parkinson's disease for the development of neuronal fingerprints using artificial intelligence.

Journal: BMJ open
PMID: 40379316

Abstract

INTRODUCTION: Deep brain stimulation (DBS) is a proven effective treatment for Parkinson's disease (PD). However, titrating DBS stimulation parameters is a labourious process and requires frequent hospital visits. Additionally, its current application uses continuous high-frequency stimulation at a constant intensity, which may reduce efficacy and cause side effects. The objective of the AI-DBS study is to identify patient-specific patterns of neuronal activity that are associated with the severity of motor symptoms of PD. This information is essential for the development of advanced responsive stimulation algorithms, which may improve the efficacy of DBS.

Authors

  • Mariëlle J Stam
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands m.j.stam@amsterdamumc.nl.
  • Martijn G J de Neeling
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Bart J Keulen
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Deborah Hubers
    Department of Neurology and Clinical Neurophysiology, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands. Electronic address: d.hubers@amsterdamumc.nl.
  • Rob M A de Bie
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Rick Schuurman
    Department of Neurosurgery, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Arthur W G Buijink
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Bernadette C M van Wijk
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
  • Martijn Beudel
    Department of Neurology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.

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