Integrating bioinformatics and machine learning to identify biomarkers of branched chain amino acid related genes in osteoarthritis.

Journal: BMC musculoskeletal disorders
Published Date: May 26, 2025

Abstract

BACKGROUND: Branched-chain amino acids (BCAA) metabolism is significantly associated with osteoarthritis (OA), but the specific mechanism of BCAA related genes (BCAA-RGs) in OA is still unclear. Therefore, this research intended to identify potential biomarkers and mechanisms of action of BCAA-RGs in OA tissues.

Authors

  • Xiao-Zhi ZhaYang
    Faculty of Medical Science, Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Yan-Xiong Chen
    Faculty of Medical Science, Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Wen-Da Hua
    Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Zheng-Lin Bai
    Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Yun-Peng Jin
    Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Xing-Wen Zhao
    Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Quan-Fu Liu
    Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Zeng-Dong Meng
    Faculty of Medical Science, Kunming University of Science and Technology, Kunming, Yunnan, China. menggu7119@vip.sina.com.

Keywords

External Resources

Popular Topics
Recent Journals