Exploring the effect of the triglyceride-glucose index on bone metabolism in prepubertal children, a retrospective study: insights from traditional methods and machine-learning-based bone remodeling prediction.

Journal: PeerJ

Published Date: May 20, 2025

Abstract

BACKGROUND: Childhood obesity poses a significant risk to bone health, but the impact of insulin resistance (IR) on bone metabolism in prepubertal children, as assessed by the triglyceride-glucose (TyG) index, remains underexplored. Bone turnover markers (BTMs) provide a non-invasive method for evaluating bone remodeling, but their relationship to obesity-related metabolic changes requires further study.

Authors

Shunshun Cao

Pediatric Endocrinology, Genetics and Metabolism, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Aolei Chen

Reproductive Medicine Center, Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Botian Song

Reproductive Medicine Center, Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yangyang Hu

Reproductive Medicine Center, Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Keywords

Biomarkers Blood Glucose Bone and Bones Bone Remodeling Child Female Humans Insulin Resistance Machine Learning Male Pediatric Obesity Procollagen Retrospective Studies Triglycerides

External Resources

View on PubMed Access via DOI PubMed (40416622)

Exploring the effect of the triglyceride-glucose index on bone metabolism in prepubertal children, a retrospective study: insights from traditional methods and machine-learning-based bone remodeling prediction.

Abstract

Authors

Keywords

External Resources

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