Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...
BACKGROUND: Ultrasound-based bone surface segmentation is crucial in computer-assisted orthopedic surgery. However, ultrasound images have limitations, including a low signal-to-noise ratio, acoustic shadowing, and speckle noise, which make interpret...
Computer methods and programs in biomedicine
Apr 30, 2025
BACKGROUND AND OBJECTIVE: The full waveform inversion (FWI) method plays a significant role in bone quantitative imaging. It is shown that even a small deviation in transducer positions can lead to a considerable variation in frequency-domain signals...
Computer methods and programs in biomedicine
Apr 25, 2025
BACKGROUND AND OBJECTIVE: It is a challenging task to use ultrasound for bone imaging, as the bone tissue has a complex structure with high acoustic impedance and speed-of-sound (SOS). Recently, full waveform inversion (FWI) has shown promising imagi...
PURPOSE: Convolutional neural networks (CNNs) have been studied for detecting bone metastases on bone scans; however, the application of ConvNeXt and transformer models has not yet been explored. This study aims to evaluate the performance of various...
In bone-imaging research, in situ synchrotron radiation micro-computed tomography (SRµCT) mechanical tests are used to investigate the mechanical properties of bone in relation to its microstructure. Low-dose computed tomography (CT) is used to prese...
Drug-induced osteotoxicity refers to the harmful effects certain pharmaceuticals have on the skeletal system, posing significant safety risks. These toxic effects are critical concerns in clinical practice, drug development, and environmental managem...
Unique mechanical properties of cortical bone are defined by the arrangement and ratio of its organic and inorganic constituents. This arrangement can be influenced by ageing and disease, urging the understanding of normal and deviant morphological p...
ACS biomaterials science & engineering
Mar 19, 2025
Effective drug development for bone-related diseases, such as osteoporosis and metastasis, is hindered by the lack of physiologically relevant in vitro models. Traditional platforms, including standard tissue culture plastic, fail to replicate the st...
INTRODUCTION: Osteoporosis, a common condition characterised by decreased bone mass and microarchitectural deterioration, leading to increased fracture risk, is a significant health concern. Traditional diagnostic methods, such as Dual-energy X-ray A...
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