Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn's disease: integrating bioinformatics, machine learning, and experimental approaches.

Journal: Frontiers in immunology
Published Date: May 8, 2025

Abstract

BACKGROUND: Psoriasis and Crohn's disease (CD) are chronic inflammatory diseases that involve complex immune-mediated mechanisms. Despite clinical overlap and shared genetic predispositions, the molecular pathways connecting these diseases remain incompletely understood. The present study seeks to identify shared biomarkers and therapeutic targets for psoriasis and CD.

Authors

  • Xiaolong Li
    Auckland Tongji Medical & Rehabilitation Equipment Research Centre, Tongji Zhejiang College, Jiaxing, China.
  • Hui Cao
  • Mutian Niu
    School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, Guangxi, China.
  • Qingbo Liu
    School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, Guangxi, China.
  • Bin Liang
    Image Processing Center, Beihang University, Beijing 100191, People's Republic of China. Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People's Republic of China.
  • Junfeng Hou
    Zhejiang A&F University, College of Chemistry and Materials Engineering, Hangzhou 311300, PR China; Key Laboratory of Wood Science and Technology of Zhejiang Province, Hangzhou 311300, PR China. Electronic address: houjunfeng@zafu.edu.cn.
  • Jian Tu
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Jintao Gao
    School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, Guangxi, China.

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