AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study.

Journal: The Lancet. Digital health
Published Date:

Abstract

BACKGROUND: CT attenuation correction (CTAC) scans are routinely obtained during cardiac perfusion imaging, but currently only used for attenuation correction and visual calcium estimation. We aimed to develop a novel artificial intelligence (AI)-based approach to obtain volumetric measurements of chest body composition from CTAC scans and to evaluate these measures for all-cause mortality risk stratification.

Authors

  • Jirong Yi
    Departments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences, and Imaging, Cedars-Sinai Medical Center, 6500 Wilshire Boulevard, Los Angeles, CA 90048, USA.
  • Anna M Marcinkiewicz
    Departments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences, and Imaging, Cedars-Sinai Medical Center, 6500 Wilshire Boulevard, Los Angeles, CA 90048, USA.
  • Aakash Shanbhag
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Robert J H Miller
    Department of Imaging and Medicine and the Smidt Heart Institute (E.E., S.C., H.G., S.C., R.J.H.M., P.J.S., B.K.T., D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
  • Jolien Geers
    Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (R.J.J.M., N.M., A.L., A.S., C.P., A.K., P.M., A.R., K.G., A.C.K., D.H., K.K., G.F.T., J.G., H.G., S.C., D.S.B., P.J.S., D.D.).
  • Wenhao Zhang
    Aliyun School of Big Data, Changzhou University, 213164 Changzhou, China.
  • Aditya Killekar
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Nipun Manral
    Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Mark Lemley
    Oregon Heart and Vascular Institute, Sacred Heart Medical Center, Springfield, Oregon.
  • Mikołaj Buchwald
    Network Services Department, Poznan Supercomputing and Networking Center, Polish Academy of Sciences, Poznań, Poland.
  • Jacek Kwiecinski
    Division of Artificial Intelligence in Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Jianhang Zhou
    PAMI Research Group, Dept. of Computer and Information Science, University of Macau, Taipa, Macau, China; Shenzhen Research Institute of Big Data, Shenzhen, 518172, China. Electronic address: yc07424@um.edu.mo.
  • Paul B Kavanagh
    Departments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Joanna X Liang
    Division of Nuclear Medicine, Department of Imaging, and Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  • Valerie Builoff
    Department of Medicine (Division of Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Terrence D Ruddy
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada.
  • Andrew J Einstein
    Division of Cardiology, Department of Medicine, Columbia University Medical Center and New York-Presbyterian Hospital, New York, New York; Department of Radiology, Columbia University Medical Center and New York-Presbyterian Hospital, New York, New York.
  • Attila Feher
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.
  • Edward J Miller
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.
  • Albert J Sinusas
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
  • Daniel S Berman
    Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Damini Dey
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.
  • Piotr J Slomka
    Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California Piotr.Slomka@cshs.org.