Label-free rapid diagnosis of jaw osteonecrosis via the intersection of Raman spectroscopy and deep learning.

Journal: Bone
Published Date:

Abstract

OBJECTIVES: To establish a precise and efficient diagnostic framework for distinguishing medication-related osteonecrosis of the jaw, radiation-induced osteonecrosis of the jaw, and normal bone tissue, thus enhancing clinical decision-making and enabling targeted therapeutic interventions.

Authors

  • Xiaobo Dai
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Bowen Yang
    Song are with Center for Cyber-Physical Systems, University of Georgia, Athens, GA 30602, USA.
  • Liangjun Zhou
    College of Chemistry, Sichuan University, Chengdu 610064, China. Electronic address: zhou_lj@stu.scu.edu.cn.
  • Ran You
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Shuai Chen
    State Key Laboratory of Resources and Environmental Information Systems, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.
  • ZhongXu Li
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Xingzhi Zeng
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Zhining Wen
    College of Chemistry, Sichuan University, Chengdu, Sichuan, China.
  • Chunjie Li
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: lichunjie@scu.edu.cn.
  • Bing Yan
    Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hosipital of Xiamen University, Xiamen, China.