Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.

Journal: International journal of radiation oncology, biology, physics
Published Date: Jan 22, 2025

Abstract

This white paper examines the potential of pioneering technologies and artificial intelligence-driven solutions in advancing clinical trials involving radiation therapy. As the field of radiation therapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiation therapy, image guided radiation therapy, and artificial intelligence promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect, and the combination of radiation therapy and immunotherapy create new avenues for innovation in clinical trials. The paper aims to provide an overview of these emerging technologies and discuss their challenges and opportunities in shaping the future of radiation oncology clinical trials. By synthesizing knowledge from experts across various disciplines, this white paper aims to present a foundation for the successful integration of these innovations into radiation therapy research and practice, ultimately enhancing patient outcomes and revolutionizing cancer care.

Authors

  • Ying Xiao
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
  • Stanley Benedict
    Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, CA, United States of America.
  • Yunfeng Cui
    Duke University Medical Center, Durham, North Carolina.
  • Carri Glide-Hurst
    Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin; Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: glidehurst@humonc.wisc.edu.
  • Stephen Graves
    Department of Surgery, Epworth HealthCare, The University of Melbourne, Parkville, Victoria, Australia.
  • Xun Jia
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235.
  • Stephen F Kry
    Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Heng Li
    Department of Anesthesiology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan Province, China.
  • Liyong Lin
    Department of Radiation Oncology, University of Pennsylvania.
  • Martha Matuszak
    b Department of Radiation Oncology , University of Michigan , Ann Arbor , MI , USA.
  • Mark Newpower
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
  • Harald Paganetti
  • X Sharon Qi
  • Emilie Roncali
    Department of Biomedical Engineering, University of California, Davis, United States of America.
  • Yi Rong
    Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, CA, United States.
  • George Sgouros
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland.
  • Charles B Simone
    Department of Radiation Oncology, University of Maryland Medical Center.
  • John J Sunderland
    Department of Radiology, The University of Iowa, Iowa City, IA, 52242, USA.
  • Paige A Taylor
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Leila Tchelebi
    Department of Radiation Oncology, Northwell Health, Mt. Kisco, New York.
  • Michael Weldon
    Department of Radiation Oncology, The Ohio State University Medical Center, Columbus, Ohio.
  • Jennifer W Zou
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Evan J Wuthrick
    Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.
  • Mitchell Machtay
    114516University Hospitals Cleveland Medical Center, Cleveland, USA.
  • Quynh-Thu Le
    Department of Radiation Oncology, Stanford University School of Medicine , Stanford, California 94305, United States.
  • Jeffrey C Buchsbaum
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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