Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea.

Journal: Archivos de bronconeumologia
Published Date: Dec 5, 2024

Abstract

INTRODUCTION: Understanding the diverse pathogenetic pathways in obstructive sleep apnea (OSA) is crucial for improving outcomes. microRNA (miRNA) profiling is a promising strategy for elucidating these mechanisms.

Authors

  • Thalia Belmonte
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
  • Iván D Benitez
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Department of Basic Medical Sciences, University of Lleida, Lleida, Spain.
  • María C García-Hidalgo
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
  • Marta Molinero
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
  • Lucía Pinilla
    CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Precision Medicine in Chronic Diseases, University Hospital Arnau de Vilanova and Santa Maria, IRB Lleida, Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain.
  • Olga Mínguez
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
  • Rafaela Vaca
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
  • Maria Aguilà
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
  • Anna Moncusí-Moix
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
  • Gerard Torres
    CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Precision Medicine in Chronic Diseases, University Hospital Arnau de Vilanova and Santa Maria, IRB Lleida, Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain.
  • Olga Mediano
    Pneumology Department, University Hospital of Guadalajara, Guadalajara, Spain.
  • Juan F Masa
    San Pedro de Alcantara Hospital, Instituto Universitario de Investigación Biosanitaria de Extremadura, Cáceres, Spain.
  • Maria J Masdeu
    Respiratory and Sleep Department, Parc Taulí University Hospital, Parc Taulí Research and Innovation Institute, Autonomous University of Barcelona, Sabadell, Spain.
  • Blanca Montero-San-Martín
    Department of Clinical Laboratory, University Hospital Arnau de Vilanova, IRBLleida, Lleida, Spain.
  • Mercè Ibarz
    Department of Clinical Laboratory, University Hospital Arnau de Vilanova, IRBLleida, Lleida, Spain.
  • Pablo Martinez-Camblor
    Anesthesiology Department, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile.
  • Alberto Gómez-Carballa
    CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Genetics, Vaccines and Infections Research Group (GenViP), Instituto de Investigación Sanitaria de Santiago, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Galicia, Spain; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela (USC) and Genetica de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Galicia, Spain.
  • Antonio Salas
    Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, GenPoB Research Group, Instituto de Investigaciones, Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
  • Federico Martinón-Torres
    CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Genetics, Vaccines and Infections Research Group (GenViP), Instituto de Investigación Sanitaria de Santiago, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Galicia, Spain; Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
  • Ferran Barbé
    Institut de Recerca Biomèdica (IRBlleida), Lleida, Spain.
  • Manuel Sánchez-de-la-Torre
    Institut de Recerca Biomèdica (IRBlleida), Lleida, Spain.
  • David de Gonzalo-Calvo
    Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain. Electronic address: dgonzalo@irblleida.cat.

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