Utilising Natural Language Processing to Identify Brain Tumor Patients for Clinical Trials: Development and Initial Evaluation.

Journal: World neurosurgery
Published Date:

Abstract

BACKGROUND: Identifying patients eligible for clinical trials through eligibility screening is time and resource-intensive. Natural Language Processing (NLP) models may enhance clinical trial screening by extracting data from Electronic Health Records (EHRs).

Authors

  • James Booker
    Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK.
  • Jack Penn
    Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK.
  • Kawsar Noor
    Health Data Research UK London, University College London, London, UK; Institute of Health Informatics, University College London, London, UK; NIHR BRC Clinical Research Informatics Unit, University College London Hospitals, NHS Foundation Trust, London, UK.
  • Richard J B Dobson
    Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, UK.
  • Naomi Fersht
    Department of Oncology, National Hospital for Neurology and Neurosurgery, London, UK.
  • Jonathan P Funnell
    Department of Neurosurgery, St George's Hospital, London, United Kingdom.
  • Ciaran S Hill
    National Hospital for Neurology and Neurosurgery, University College London NHS Trust, London, United Kingdom.
  • Danyal Z Khan
    Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College, London, United Kingdom; Wellcome EPSRC Centre for Interventional and Surgical Sciences, University College, London, United Kingdom.
  • Nicola Newall
    Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK.
  • Tom Searle
    NIHR Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust and King's College London, London, UK.
  • Siddharth Sinha
    Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.
  • Lewis Thorne
    Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH Foundation Trust, London, UK.
  • Simon C Williams
    Department of Neurosurgery, St George's Hospital, London, United Kingdom.
  • Michael Kosmin
    NIHR Biomedical Research Centre, University College London Hospitals National Health Service Foundation Trust, London, UK; Department of Oncology, National Hospital for Neurology and Neurosurgery, London, UK.
  • Hani J Marcus
    The Hamlyn Centre for Robotic Surgery, Institute of Global Health Innovation, Imperial College London, Paterson Building (Level 3), Praed Street, London, W2 1NY, UK, hani.marcus10@imperial.ac.uk.