Multi-dimensional characterization of cellular states reveals clinically relevant immunological subtypes and therapeutic vulnerabilities in ovarian cancer.

Journal: Journal of translational medicine
PMID: 40340848

Abstract

BACKGROUND: Diverse cell types and cellular states in the tumor microenvironment (TME) are drivers of biological and therapeutic heterogeneity in ovarian cancer (OV). Characterization of the diverse malignant and immunology cellular states that make up the TME and their associations with clinical outcomes are critical for cancer therapy. However, we are still lack of knowledge about the cellular states and their clinical relevance in OV.

Authors

  • Can Zhang
  • Si Li
    School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, 150081, China.
  • Jiyu Guo
    School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, 150081, China.
  • Tao Pan
    College of Biomedical Information and Engineering, Hainan Medical University, Haikou, 571199, China.
  • Ya Zhang
    Department of Plant Protection, College of Plant Protection, Hunan Agricultural University, Changsha, China. Electronic address: zhangya230@126.com.
  • Yueying Gao
    School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, 150081, China.
  • Jiwei Pan
    College of Biomedical Information and Engineering, Hainan Medical University, Haikou, 571199, China.
  • Meng Liu
  • Qingyi Yang
    School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, 150081, China.
  • Jinyang Yu
    College of Biomedical Information and Engineering, Hainan Medical University, Haikou, 571199, China.
  • Juan Xu
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China. xujuanbiocc@ems.hrbmu.edu.cn.
  • Yongsheng Li
    School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, 150081, China. liyongsheng@ems.hrbmu.edu.cn.
  • Xia Li
    Research Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.

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