Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

Journal: Journal of neuroscience methods
Published Date: May 16, 2025

Abstract

BACKGROUND: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its ability to stimulate neuronal activities without needing exogenous agents. NIR light is absorbed by water of the tissue producing local thermal effects. Therefore, INS is a suitable candidate for localized and targeted neural stimulation. However, despite the wide variety of research studies on INS applications, limited studies have focused on identifying and optimizing the stimulation parameters to avoid potential excitotoxicity. This study evaluates the dorsal root ganglia (DRG) neurons' response under INS with varying intensities and illumination time.

Authors

  • Parinaz Abdollahian
    DTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, Lyngby, Denmark; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Kunyang Sui
    DTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, Lyngby, Denmark; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Guanghui Li
    State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.
  • Rune W Berg
    Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Marcello Meneghetti
    DTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, Lyngby, Denmark; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Christos Markos
    DTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, Lyngby, Denmark. Electronic address: chmar@dtu.dk.

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