Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.

Journal: Frontiers in immunology
Published Date: May 23, 2025

Abstract

INTRODUCTION: Pancreatic cancer (PC) remains a lethal malignancy with limited treatment options. The role of innate immune cell barrier-related genes in PC prognosis is poorly defined. This study aimed to identify prognostic biomarkers, develop a predictive model, and uncover novel targets for personalized therapy.

Authors

  • Qiang Luo
    Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, PR China; Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, PR China. Electronic address: qluo@fudan.edu.cn.
  • Tingting Jiang
    Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, 06511, CT, USA.
  • Dacheng Xie
    Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China.
  • Xiaojia Li
    Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, Guangdong, China.
  • Keping Xie
    Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, Guangdong, China.

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