Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine.

Journal: Current urology reports
Published Date: May 26, 2025

Abstract

PURPOSE OF REVIEW: Renal cell carcinoma (RCC) is a prevalent and increasingly diagnosed malignancy associated with high mortality and recurrence rates. Traditional diagnostic and therapeutic approaches have limitations due to the disease's molecular heterogeneity. This review aims to explore how the integration of omics sciences-genomics, transcriptomics, proteomics, and metabolomics-can enhance the diagnosis, prognosis, and treatment of RCC.

Authors

  • Filippo Gavi
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy. filippo.gavi@guest.policlinicogemelli.it.
  • Maria Chiara Sighinolfi
    Department of Urology. University of Modena and Reggio Emilia. Modena. Italy.
  • Giuseppe Pallotta
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Simone Assumma
    Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S. Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy.
  • Enrico Panio
    Urology Unit, ASST Santi Paolo and Carlo, Via Rudini 8, Milan, Italy.
  • Daniele Fettucciari
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Antonio Silvestri
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Pierluigi Russo
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Riccardo Bientinesi
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Nazario Foschi
    Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Filippo Turri
    Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.
  • Umberto Carbonara
    Division of Urology, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.
  • Chiara Ciccarese
    Department of Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Roberto Iacovelli
    Department of Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00168, Italy.
  • Camilla Nero
    Fondazione Policlinico Agostino Gemelli, IRCCS, Gynecology and Obstetrics, 00168 Rome, Italy.
  • Bernardo Rocco
    Department of Urology, University of Central Florida College of Medicine and Global Robotics Institute, Florida Hospital-Celebration Health, Celebration, FL, USA.

Keywords

External Resources

Popular Topics
Recent Journals