Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceus.

Journal: Journal of orthopaedic surgery and research
Published Date: May 30, 2025

Abstract

BACKGROUND: Macrophage polarization exacerbates the pathological processes of osteoarthritis (OA). Astragalus membranaceus (AM) can repair chondrocytes and serve as a protective agent for OA. Therefore, the study intended to identify macrophage polarization-related genes (MPRGs) in the treatment of OA with AM.

Authors

  • Hui Zang
    Shanghai Ocean University, Shanghai, 201306, China.
  • Liuyan Wang
    Shanghai Ocean University, Shanghai, 201306, China.
  • Yang Wu
  • Junfei Chang
    Shanghai Ocean University, Shanghai, 201306, China.
  • Wanjun Liu
    Shanghai Ocean University, Shanghai, 201306, China. 72500L10067@shsmu.edu.cn.

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