OBJECTIVE: This study aimed to identify diagnostic biomarkers for keloid and explore potential therapeutic agents from traditional Chinese medicine (TCM) by integrating network pharmacology approaches. Specifically, we sought to uncover key molecular...
Medical oncology (Northwood, London, England)
Dec 24, 2025
Non-small cell lung cancer (NSCLC) presents significant therapeutic challenges due to resistance and immune evasion. Dihydroartemisinin (DHA), a derivative of artemisinin, exhibits broad anti-tumor activity, but its molecular targets and mechanisms i...
Biochemical and biophysical research communications
Dec 17, 2025
The dry fruits of Amomum villosum (Av) are a traditional Chinese medicine used for gastrointestinal disease. Aromatic oil has been reported to have anti-tumor properties. However, its therapeutic potential and molecular mechanisms remain unclear. Int...
Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic efficacy. Chinese herbal medicines (CHMs) offer multi-target potential, yet their systematic screening and mechanistic elucidation remain challenging. We...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Oct 24, 2025
BACKGROUND: As global health challenges continue to evolve, herbal medicines (HMs) have garnered significant scientific interest as a valuable resource for treating complex diseases. However, the chemical complexity of HMs presents considerable chall...
Pholiota adiposa is recognized for its health benefits, particularly in Alzheimer's disease (AD), but its molecular mechanism remains elusive. Our study employs network pharmacology and machine learning to uncover its therapeutic potential. We constr...
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
ETHNOPHARMACOLOGICAL RELEVANCE: Angong Niuhuang Pills (AGNHP), a famous Chinese medicine compound preparation, is widely used to treat stroke and other brain disorders. However, owing to the complexity of herbal components and diversity of production...
Journal of orthopaedic surgery and research
May 30, 2025
BACKGROUND: Macrophage polarization exacerbates the pathological processes of osteoarthritis (OA). Astragalus membranaceus (AM) can repair chondrocytes and serve as a protective agent for OA. Therefore, the study intended to identify macrophage polar...
Glycyrrhiza glabra (G. glabra) phytocompounds have been reported to interact with neurological targets, including those implicated in epilepsy, and may modulate epilepsy-related targets. While substantial evidence supports their potential antiepilept...
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