AIMC Topic: Macrophage Activation

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SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

International immunopharmacology
Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes, and appl...

Specificity protein 1 suppresses prohibitin 1 to induce macrophage M1 polarization and impair phagocytosis, exacerbating sepsis-associated acute lung injury.

Free radical biology & medicine
Sepsis-related acute lung injury (ALI) is a severe and life-threatening complication characterized by excessive inflammation and immune dysfunction. Macrophages play a central role in the pathogenesis of ALI, with dysregulated polarization and impair...

Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceus.

Journal of orthopaedic surgery and research
BACKGROUND: Macrophage polarization exacerbates the pathological processes of osteoarthritis (OA). Astragalus membranaceus (AM) can repair chondrocytes and serve as a protective agent for OA. Therefore, the study intended to identify macrophage polar...

Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proceedings of the National Academy of Sciences of the United States of America
We present a method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy. The retrieved parameters are related to different attributes of the c...

Ptgs2+ CPTC Function as a "Force-Immune Axis" by Responding to Acupuncture and Mediating M2 Macrophage Activation for Anti-Inflammatory Effects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Recent advancements have highlighted the imperative for cytological exploration of fascial tissues. Telocytes, specialized interstitial cells found in connective tissues such as fascia, have garnered significant attention. Our study explored the cell...

Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy.

Clinical and experimental medicine
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...