Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries.

Journal: BMC oral health
Published Date: May 31, 2025

Abstract

BACKGROUND: Early childhood caries (ECC) is a widespread pediatric dental condition that is influenced by a combination of biological, behavioral, and demographic factors. Salivary biomarkers, including beta-defensin-2 (BD-2) and statherin (STATH), offer potential as non-invasive tools for detecting and assessing the risk of ECC. This study aims to compare the levels of salivary statherin and beta-defensin-2, alongside oral health behaviors and demographic factors, in children both with and without early childhood caries.

Authors

  • Maryam Koopaie
    Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, North Kargar St, P.O.BOX:14395-433, Po. Code, Tehran, 14399-55991, Iran. mariakoopaie@gmail.com.
  • Faezeh Khajehreza Shahri
    Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, P.O.BOX:14395 -433, North Kargar St, Tehran, 14399-55991, Iran.
  • Roshanak Montazeri
    Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Sajad Kolahdooz
    Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.
  • Majid Mardani Shahri
    Department of Industrial and Systems Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Elham Moshkbouy
    Universal Scientific Education and Research Network (USERN), Tehran, Iran.

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