A novel approach to finding the compositional differences and biomarkers in gut microbiota in type 2 diabetic patients via meta-analysis, data-mining, and multivariate analysis.

Journal: Endocrinologia, diabetes y nutricion
Published Date: Jan 1, 2025

Abstract

BACKGROUND/PURPOSE OF THE STUDY: Type 2 diabetes mellitus (T2DM)-one of the fastest globally spreading diseases-is a chronic metabolic disorder characterized by elevated blood glucose levels. It has been suggested that the composition of gut microbiota plays key roles in the prevalence of T2DM. In this study, a novel approach of large-scale data mining and multivariate analysis of the gut microbiome of T2DM patients and healthy controls was conducted to find the key compositional differences in their microbiota and potential biomarkers of the disease.

Authors

  • Faezeh Ebrahimi
    Faculty of Life Sciences and Biotechnology, Department of Microbiology and Microbial Biotechnology, Shahid Beheshti University, Tehran, Iran. Electronic address: fae.ebrahimi@mail.sbu.ac.ir.
  • Hadi Maleki
    Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran 1983963113, Iran. Electronic address: ha_maleki@sbu.ac.ir.
  • Mansour Ebrahimi
    Department of Biology, School of Basic Science, University of Qom, Qom, Iran.
  • Amir Hossein Beiki
    Department of Biology, Faculty of Basic Sciences, University of Qom, Qom, Iran.

Keywords

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