Upregulation of immune genes in the proliferative phase endometrium enables classification into women with recurrent pregnancy loss versus controls.

Journal: Human reproduction (Oxford, England)
Published Date: Jun 1, 2025

Abstract

STUDY QUESTION: Does the transcriptome of preconceptional endometrium in the proliferative phase show a specific profile in women with recurrent pregnancy loss (RPL)?

Authors

  • Laerke H J Andersen
    Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Roskilde, Denmark.
  • Raquel Sanz Martinez
    The ReproHealth Research Consortium, Zealand University Hospital, Køge, Denmark.
  • Yifan Dai
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
  • Jens Ole Eriksen
    The ReproHealth Research Consortium, Zealand University Hospital, Køge, Denmark.
  • Maria K Gerlach
    Department of Pathology, Hvidovre Hospital, Hvidovre, Denmark.
  • Lise Grupe Larsen
    The ReproHealth Research Consortium, Zealand University Hospital, Køge, Denmark.
  • Nicholas S Macklon
    The ReproHealth Research Consortium, Zealand University Hospital, Køge, Denmark.
  • Kristine Juul Hare
    Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Albin Sandelin
    Section for Computational and RNA Biology, Department of Biology & Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
  • Henriette Svarre Nielsen
    Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Thomas Vauvert F Hviid
    Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Roskilde, Denmark.

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