AIMC Topic: Abortion, Habitual
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TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning.
BMC pregnancy and childbirth
May 31, 2025
BACKGROUND: Recurrent pregnancy loss (RPL), characterized by multiple miscarriages, remains a condition with unclear etiology, posing significant challenges for affected women and couples. This study aims to explore the underlying mechanisms of RPL, ...
Shared diagnostic genes and potential mechanisms between polycystic ovary syndrome and recurrent miscarriage revealed by integrated transcriptomics analysis and machine learning.
Frontiers in endocrinology
Sep 27, 2024
OBJECTIVE: More and more studies have found that polycystic ovary syndrome (PCOS) is significantly associated with recurrent spontaneous abortion (RSA), but the specific mechanism is not yet clear.
Optimizing evaluation of endometrial receptivity in recurrent pregnancy loss: a preliminary investigation integrating radiomics from multimodal ultrasound via machine learning.
Frontiers in endocrinology
Aug 20, 2024
BACKGROUND: Recurrent pregnancy loss (RPL) frequently links to a prolonged endometrial receptivity (ER) window, leading to the implantation of non-viable embryos. Existing ER assessment methods face challenges in reliability and invasiveness. Radiomi...
Machine Learning (ML) based-method applied in recurrent pregnancy loss (RPL) patients diagnostic work-up: a potential innovation in common clinical practice.
Scientific reports
May 14, 2020
RPL is a very debated condition, in which many issues concerning definition, etiological factors to investigate or therapies to apply are still controversial. ML could help clinicians to reach an objectiveness in RPL classification and access to care...
ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.
The Kaohsiung journal of medical sciences
Dec 20, 2016
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this ...
Upregulation of immune genes in the proliferative phase endometrium enables classification into women with recurrent pregnancy loss versus controls.
Human reproduction (Oxford, England)
Jun 1, 2025
STUDY QUESTION: Does the transcriptome of preconceptional endometrium in the proliferative phase show a specific profile in women with recurrent pregnancy loss (RPL)?
High throughput recurrent pregnancy loss screening: urine metabolic fingerprints LDI-MS and machine learning.
The Analyst
May 12, 2025
Infertility is a significant challenge faced by many families worldwide, with recurrent pregnancy loss (RPL) being a prevalent cause of infertility among women. This condition causes immense emotional and physical distress for affected individuals an...
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