The efficacy and toxicity equilibrium of emodin for liver injury: A bidirectional meta-analysis and machine learning.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
Published Date: Apr 11, 2025

Abstract

BACKGROUND: Emodin, a hepatoprotective agent derived from various herbs, exhibits dual effects on liver injury, necessitating further investigation into its therapeutic and toxic properties. Traditional meta-analyses lack predictive capability for dose- and duration-dependent effects. This study uniquely employs meta-analysis to confirm both hepatoprotective and hepatotoxic effects of emodin and uses machine learning to predict critical thresholds where these effects invert.

Authors

  • Sihan Hu
    Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital; Institute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, PR China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
  • Xiaochuan Guo
    Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, PR China.
  • Lang Tu
    West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Huiling Xiong
    State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
  • Xiaohua Lu
    Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
  • Xinyi Xu
    School of Micro-Nano Electronics, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310027, China.
  • Yilai Li
    State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
  • Yibing Yu
    Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital; Institute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, PR China.
  • Chenyang Zhou
    Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Kunpeng Hui
    Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital; Institute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, PR China.
  • Yeyu Li
    Hospital of Chengdu University of Traditional Chinese Medicine, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China. Electronic address: 570725015@qq.com.
  • Jinhao Zeng
    TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: zengjinhao@cdutcm.edu.cn.
  • Xiao Ma
    Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Thomas Efferth
    Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Germany.

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