AIMC Topic: Protective Agents

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Protective effects of minocycline on dermal fibroblast cells from oxidant and apoptotic effects of HO: A comprehensive analysis with Raman spectroscopy and data-driven approach.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Minocycline (Mino) is an antibiotic with neuroprotective, anti-inflammatory, and antioxidant properties. This study investigated the protective effects of Mino against hydrogen peroxide (HO)-induced oxidative damage in dermal fibroblast cells and ana...

The efficacy and toxicity equilibrium of emodin for liver injury: A bidirectional meta-analysis and machine learning.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Emodin, a hepatoprotective agent derived from various herbs, exhibits dual effects on liver injury, necessitating further investigation into its therapeutic and toxic properties. Traditional meta-analyses lack predictive capability for do...

Preparation, characterization, and protective effects of carbon dots against oxidative damage induced by LPS in IPEC-J2 cells.

Frontiers in cellular and infection microbiology
This study aimed to prepare carbon dots (GF-CDs) and examine their efficacy in mitigating oxidative stress and apoptosis in intestinal porcine epithelial cells from the jejunum (IPEC-J2 cells) induced by lipopolysaccharide (LPS). The GF-CDs were syn...

Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend.

Nature aging
Aging involves metabolic changes that lead to reduced cellular fitness, yet the role of many metabolites in aging is unclear. Understanding the mechanisms of known geroprotective molecules reveals insights into metabolic networks regulating aging and...

The use of geroprotectors to prevent multimorbidity: Opportunities and challenges.

Mechanisms of ageing and development
Over 60 % of people over the age of 65 will suffer from multiple diseases concomitantly but the common approach is to treat each disease separately. As age-associated diseases have common underlying mechanisms there is potential to tackle many diseas...

[In vitro Modulating Activity of aqueous extracts from American Plants on Chlorpyrifos-induced toxicity on Murine Splenocytes].

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)
BACKGROUND: Chlorpyrifos is an highly toxic pesticide, which can induce immunotoxicity with deleterious effects on health worldwide. On the other hand, American plants can provide derivatives with protective and immunostimulating activity. Thus, plan...

Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...

Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Atherosclerosis, the leading cause of cardiovascular diseases in the world, is a chronic inflammatory disorder characterized by the dysfunction of arteries. Oleanolic acid (OA) is a bioactive nature product which exists in various plants and herbs. P...